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Smart Drug Noopept powder Review, Benefits, Dosages &
Side Effects
1.What is Noopept?
Noopept is a nootropic supplement that’s been getting a lot of attention lately. It has close ties to the popular racetam family of nootropics that are known for their benefits on cognitive ability as well their neuroprotective properties. What makes Noopept a particularly unique nootropic in your toolbox is that its effects are felt almost immediately after ingestion.
Many nootropics can take days, weeks, or even months, for their full effects to kick in but Noopept is another story. Another nootropic that compares to Noopept’s immediate effects is phenylpiracetam.
Currently, Noopept CAS 157115-85-0 is being prescribed and distributed in Russia and its surrounding countries for its nootropic properties. Its popularity has drastically increased and is now distributed worldwide.
Noopept as a nootropic is commonly compared to piracetam and aniracetam. It works via a similar mechanism as piracetam but is estimated to be 1,000 to 5,000 times more potent. Its impressive potency doesn’t imply that its effect is more profound; it simply attunes itself better to the brain’s receptors, and as a result, Noopept can be taken in relatively smaller doses to produce similar effects as that of Piracetam.
Noopept is also very inexpensive when compared to other nootropics because of how potent it is per milligram. Its effectiveness and affordable cost per dose have made it a favorite among the nootropic community.
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Name: Noopept(GVS-111) powder
CAS: 157115-85-0
Molecular Formula: C17H22N2O4
Molecular Weight: 318.37
Melt Point: 97-98°C
Storage Temp: Refrigerator
Color: White or off white Crystalline powder
Users of Noopept report results of improved clarity, better memory, and focus. More studies are required to determine exactly how Noopept delivers its benefits to the human brain. Studies on animals have shown that Noopept increased alpha/beta1 activity in all brain areas.
In humans, based on observational, uncontrolled studies, Noopept demonstrated rehabilitative benefits to patients with mild cognitive disorders. Currently, Noopept tablets are undergoing clinical assessment as a way of treating cognitive deficiency of post-traumatic origin and cerebrovascular cause. The brain benefits are derived from antioxidant action, anti-inflammatory properties, and the inhibition of toxicity with the elimination of excess glutamate and calcium. It was also observed that blood composition and flow were improved.
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Taken orally, Noopept CAS 157115-85-0 is absorbed by the digestive system and then readily crosses the blood-brain barrier. When administered in the proper dosages, it is nearly completely used by the brain, and very little is wasted. Noopept targets glutamate receptor sites where it is believed to bind with the glutamate and inhibit breakdown. Glutamate, being one of the most powerful neurotransmitters, supports and expands cognitive functioning.
Noopept acts quickly once it is in the bloodstream, maximizing concentration after just 15 to 20 minutes. Advocates of the supplement report the flooding of clarity brought on by the immediate advantage of additional oxygen to the brain and improved glucose use. Many individuals report improved vision and sharper, more vibrant colors. Others have even reported enhanced hearing following just a short period of usage.
4.Dosage of Noopept powder
Due to its incredible potency, the recommended dosage of Noopept is relatively small, usually 10 to 20 mg taken as often as three times daily. Dosage should not exceed 40 mg in a 24-hour period.
Since the body metabolizes Noopept rapidly, and it has a very short half-life in the human body, it is preferable to take multiple small doses versus one large dose to extend Noopept’s acute effects.
When starting out with Noopept, we recommend a starting with the minimum effective dose, with careful observation, before increasing dosage. Each person should determine their own optimum dosage.
In powder form, Noopept CAS 157115-85-0 is usually placed under the tongue or mixed with water and drunk. Effects are felt quickly after administration, as fast as within 15 minutes.
According to the dosing label that comes in the packet insert in Russia, it is recommended to take Noopept for 1.5-3 weeks and then, if necessary, to begin another cycle after a
It is not recommended to take Noopept late in the evening as its energizing effects may interfere with sleep.
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To have a better understanding of what Noopept can do, let’s enumerate its key benefits:
Memory and Learning
Noopept’s most emphasized benefit is how it can enhance memory and improve the learning process. Noopept, like Piracetam, assists with memory formation, but with additional benefits not present in the latter, which are memory consolidation and memory retrieval. Noopept facilitates the proper management of all forms of stimuli as they are processed by the brain, which allows for better memory retrieval. In other words, signals being processed by our senses are more streamlined as they are transported into our brains in the form of memory.
Through the continued use of Noopept, you will likely notice that you can digest more information and process it more readily for use in your daily activities. You might even recall names, places, maybe a word spoken in a chance encounter, a song title that you thought you had forgotten before, and so on.
Neuroprotective Properties
Studies show that Noopept has high neuroprotective properties. The stimulation of the neurons caused by the health supplement prevents oxidative damage and apoptosis in the human brain. Many patients dealing with cognitive impairment regularly can benefit from a regular dosage of Noopept to prevent further dissociative cognitive functions.
Increased levels of NGF
NGF (Nerve Growth Factor) is a unique protein in the body that is involved in the growth, maintenance, and survival of nerve cells, including brain cells. NGF is also considered to be a key player in neurogenesis, your body’s ability to create new cells.
By increasing NGF levels in the brain, we support the mechanisms involved in neurogenesis which improves the performance of neural networks within the brain, allowing for new neural connections. The result means potentially improved mental abilities in virtually all areas of cognition.
Increased levels of BDNF
BDNF (Brain-Derived Neurotrophic Factor) is another protein in the body that has a similar role to the NGF mentioned above. BDNF is considered one of the most important
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molecules involved in memory, playing a vital role in both short-term and long-term memory formation.
Improves Associations between Brain Hemispheres
Both the right and left hemispheres of the brain have their own localized functions. Through the use of Noopept, each of these functions can be enhanced through the synthesis of various memories, ideas, and stimuli. There are nuances among these functions that enhance the way we think. That is why a lot of people have claimed that their quality of life had a significant improvement from taking Noopept on a regular basis.
6.Noopept powder Stacks
It is interesting to note that the practice of stacking supplements originated with athletes looking to gain extra advantages by synergizing the pathways of several different compounds.
Stacking, for those who might not be familiar with the term, is the practice of taking two or more supplements together in an effort to gain additional benefits or to intensity specific effects.
This practice has now carried over into the world of Nootropics and cognitive enhancers.
By using Noopept with other nootropics, you can actually see improvements above and beyond what you would see if you were using different compounds independently.
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Many users might be wondering exactly what to use in a Noopept stack and how to use these nootropic combinations properly.
In this article we will look at some of the best Noopept stacks used today as well as address concerns about potential side effects and whether it might be a good idea to cycle your stack.
7.Noopept powder overview
Noopept is one of the most recent nootropics developed. This compound was designed to be an improvement over many of the ‘older’ nootropics like Piracetam. It has higher bio availability, meaning that more of the actual substance is usable by the body.
Additionally, Noopept is estimated to be between 1,000 and 5,000 times as potent as the original nootropics (i.e. Piracetam), making it the strongest available analogue of Piracetam. This compound is believed to work by binding to Glutamate receptors in the brain, augmenting the effectiveness of this neurotransmitter.
It is thought that Glutamate is another of the brain chemicals responsible for memory functions, and that Noopept may help increase its activity.
One of the major effects of Noopept is that it thought to improve communication between both hemispheres of the brain, just like Piracetam. It is also a neuroprotector, helping to protect neurons and brain cells from damage.
Many users have also noticed increased memory, improved general cognition, increased alertness, focus, concentration, and mental energy. Another big benefit is improved mental fluidity; many users find themselves reading, writing, and thinking with much less effort.
There is some research to suggest that Noopept may lead to a relaxing and comfortable feeling. It may help to reduce stress and fight fatigue, along with preventing oxidative damage.
The biggest difference between Piracetam and Noopept is the potency of these compounds. Noopept is much more potent substance than Piracetam and its effects are said to be stronger. The cognitive effects reported with both compounds are fairly similar, but users who have taken both have reported that Noopept is much stronger than Piracetam and takes effect more quickly.
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8.How to Prevent Noopept Side Effects
There are a number of factors that can influence whether and to what extend side effects will occur with Noopept. Some of the most significant factors include: dosage, other supplements, duration of use, source, and time taken.
Most Noopept side effects are more likely to occur at higher doses, particularly those associated with visual disturbances. Higher doses are associated with a greater number and severity of side effect.
Megadoses are likely to cause more significant changes in neurophysiology and neurotransmission. Consumption of large amounts of substances that affect neurochemistry is going to cause more pronounced effects, both desired and undesired.
Users who take higher doses of Noopept, in the range of 30mg/day, are more likely to experience unwanted side effects. At dosages greater than 60mg/day, side effects may become even more pronounced.
Conversely, those users who take standard therapeutic doses, in the range of 10-20mg/day or less, are unlikely to experience any significant side effects.
Other supplements and drugs can interact with Noopept in unexpected ways. Because this smart drug is not well researched, and its mechanisms are not fully understood, it is hard to predict how it will interact with other supplements.
For this reason, it is important to be aware that combinations with other supplements may increase the likelihood of some side effects.
It is thought that Noopept is partially metabolised in the liver by the CYP3A4 isoenzymes. Substances that influences the function of this isoenzyme is likely to influence its potency. For example, drugs that inhibit this enzyme may increase the effects.
Some side effects, particularly those related to sleep and arousal, are more likely to occur when taking Noopept later in the day.
If you find that it makes you restless or unable to relax, or if you have trouble sleeping when taking Noopept, try using it early in the morning.
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If you find that Noopept slows you down and makes you drowsy, you may wish to experiment with taking it in the evening and see if it improves the quality of your sleep.
It is also important to consider using choline with Noopept. It is thought that Noopept depletes choline levels, leading to a possible deficiency, which may explain some side effects.
However, too much choline also carries its own possibility of side effects. It may take some time and experimentation to find optimal levels of both choline and Noopept to get the best results for you.
How long you continue to use this nootropic agent may also affect which side effects you experience. Some users find that some side effects diminish with continued use, while extended use may increase some side effects.
If you experience negative effects when first using Noopept, be aware that you may need to adjust the dose. If side effects are pronounced, it may be helpful to decrease your dose for a time or temporarily cycle off of it.
Certain side effects may only become noticeable after extended use. This may be a sign of tolerance forming or it may be related to other factors like diet, supplements used, or individual neurochemistry.
In these situations, it may be beneficial to discontinue Noopept for a few months to give yourself a break.
Where you acquire your Noopept can play a big role in which side effects you experience. Contaminated or impure nootropic products acquired from a low-quality vendor is a major risk.
It is even possible to get a counterfeit product or to get Noopept that contains chemicals that could produce an allergic reaction. All high-quality vendors will conduct lab testing to ensure this is not the case.
Because users cannot generally confirm the purity and authenticity of the product they are buying, it is critical to buy Noopept from reliable and ethical vendors. To do otherwise means an increased risk of unwanted effects, and can even damage your health.
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9.Piracetam vs Noopept: Which Nootropic is Best?
(1)Piracetam Review
Piracetam was actually the first nootropic developed, initially synthesized in 1964.
It is actually able to cross over the blood-brain barrier and works very quickly. It is believed to work by improving the functioning of Acetylcholine receptors and transmitters within the brain.
Acetylcholine is a very powerful neurotransmitter that is believed to play a critical role in a number of functions including mood, memory, learning, and possibly even thought processes.
By increasing the levels of circulating Acetylcholine, Piracetam is thought have a number of very helpful effects, including increasing concentration and focus, enhancing learning capabilities, and improving the formation and recall of memories.
Piracteam is thought to help improve communication between both hemispheres of the brain. There are also significant cognitive benefits including improved memory, enhanced learning, better mental energy, cognition, and focus. Another interesting benefit that has been seen with Piracetam is that it helps to protect the cerebral cortex against a loss of oxygen.
Incidentally, Piracetam has also been used to help with conditions like OCD disorders, post-stroke aphasia, epilepsy, and even cognitive decline after heart or brain surgery. Many researchers are also exploring additional uses for Piracetam in relation to lowering depression and anxiety, and use for age-related cognitive decline seen in conditions like Alzheimer’s disease and dementia.
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Noopept is one of the most recent nootropics developed. This compound was designed to be an improvement over many of the ‘older’ nootropics like Piracetam. It has higher bio availability, meaning that more of the actual substance is usable by the body.
Additionally, Noopept is estimated to be between 1,000 and 5,000 times as potent as the original nootropics (i.e. Piracetam), making it the strongest available analogue of Piracetam. This compound is believed to work by binding to Glutamate receptors in the brain, augmenting the effectiveness of this neurotransmitter.
It is thought that Glutamate is another of the brain chemicals responsible for memory functions, and that Noopept may help increase its activity.
One of the major effects of Noopept is that it thought to improve communication between both hemispheres of the brain, just like Piracetam. It is also a neuroprotector, helping to protect neurons and brain cells from damage.
Many users have also noticed increased memory, improved general cognition, increased alertness, focus, concentration, and mental energy. Another big benefit is improved mental fluidity; many users find themselves reading, writing, and thinking with much less effort.
There is some research to suggest that Noopept may lead to a relaxing and comfortable feeling. It may help to reduce stress and fight fatigue, along with preventing oxidative damage.
The biggest difference between Piracetam and Noopept is the potency of these compounds. Noopept is much more potent substance than Piracetam and its effects are said to be stronger. The cognitive effects reported with both compounds are fairly similar, but users who have taken both have reported that Noopept is much stronger than Piracetam and takes effect more quickly.
(3)Research Comparison Piracetam with Noopept
In one study, patients with traumatic brain injury or cognitive decline due to cerebrovascular disease were given either 20 mg of Noopept daily or 1,200 mg of Piracetam.
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Patients taking noopept experienced greater improvements in mood, anxiety, fatigue, sleep, muscle weakness, attention, memory and cognitive function. They also had higher increases in their scores on a Mini-Mental State Examination (MMSE).
Those taking Piracetam experienced more variable responses to the nootropic drug and benefits took a longer period of time to be discernable. Patients did experience reductions in daytime drowsiness, fatigue, anxiety, irritability and forgetfulness. There were improvements in speech, activity levels, attention and concentration.
According to the study authors, there were no significant difference in the range of the nootropic effects between the two, but that Noopept produced a better profile of effects with fewer psychostimulatory side effects.
Piracetam did not cause the same anxiolytic effect as noopept and there was no positive benefit for sleep. Noopept produced a greater benefit for normalizing autonomic nervous system function.
(4)Comparing Side Effects
Nootropics are generally considered to be very safe. Of course, nothing works exactly the same for everyone, since different bodies have different chemistry.
Piracetam side effects are considered to be fairly rare, with only about 10% of users every reporting any effects. The side effects that are most commonly reported are all mild and can include some nervousness, agitation, weight gain, and headaches. Most side effects only occur when extremely high doses are consumed.
The most common side effect, headaches, is believed to be not due to the Piracetam directly, but instead because of its relationship with Acetylcholine. The increased Acetylcholine activity that Piracetam is thought to cause can lead to stores of this neurotransmitter becoming depleted. When this occurs it is thought to cause burn out of receptors that are still firing but have no Acetylcholine.
Adding a high quality choline supplement such as Alpha GPC or Citicoline is thought to help minimize or reduce these headaches by providing the raw materials to produce more Acetylcholine and replenish depleted stores.
It is recommended to take choline with all of the Racetams to help avoid headaches. Noopept on the other hand does not often cause headaches like these because its primary action is related to Glutamate and not Acetylcholine.
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Like Piracetam, side effects of Noopept are fairly rare, and no serious side effects have ever been reported. The most common Noopept side effects can include nervousness, irritation, restlessness, agitation, dizziness, nausea, lack of appetite, asthenia (physical weakness), heart palpitations, and insomnia.
These side effects are typically only reported when higher than recommended dosages have been taken. The best way to avoid any of these effects is to stay within the recommended dosage levels.
One comparative research study found that Noopept was safer when used as a therapeutic agent for the treatment of mild cognitive disorders. Patients taking 20 mg of Noopept daily experienced 1.8 times fewer side effects than patients taking 1,200 mg of Piracetam.
According to the researchers, “In most cases, undesirable effects on treatment with Noopept were transient and of insignificant severity. The use of piracetam was associated with a greater frequency, severity, and spectrum of undesirable effects in the patients, which were dominated by effects linked with the excessive stimulatory action of the agent, along with somatoautonomic impairments.“
(5)Recommended Dosages
Based on research studies and user reviews, Piracetam has a typical dosage range of between 1.6 and 9.6 grams per day, with most users reporting taking 4.8 g dosages two or three times per day. Dosages are typically split up into multiple equal administrations throughout the day due to the short half-life of Piracetam in the body.
Be careful taking this compound immediately before bedtime (unless interested in pursuing lucid dreams), as it can cause some people to be too alert.
Since Noopept is so much more powerful, a typical dosage is much lower. Most users report only take between 10 and 30 milligrams per day. Once again, this is most commonly split into equal administrations throughout the day.
As with any new nootropic, it is always advisable to begin with a lower dose and then only work your way up once you know how it affects your body.
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10.Aniracetam vs Noopept
Another interesting nootropic similar to Piracetam and Noopept is Aniracetam. Unlike many of the other Racetams, this one is fat soluble and is thought to possibly cross the blood-brain barrier better than the water-soluble Piracetam.
Similarly to Noopept, this nootropic exerts its influence upon Glutamate receptors, but like Piracetam it also affects Acetylcholine receptors. It is also fairly potent (but not as strong as Noopept).
The cognitive effects between Piracetam, Aniracetam, and Noopept are quite similar. An increase in memory, concentration, focus, mental energy, and general cognition are the most cited effects of Aniracetam. Aniracetam may also help to increase the rate of memory processing, which is a bit different than many of the other nootropics.
If you do not find the effects of Piracetam to be enough for your needs, but Noopept seems to be too strong, then Aniracetam may be a nice compromise for you to try.
11.Piracetam vs Noopept Conclusion
So which is the best nootropic? This is a highly personal decision and really depends upon your needs and goals. Based on user reviews, both work incredibly well, with similar cognitive effects.
If you are just starting out trying nootropics in general then it is generally recommended to start with the milder Piracetam at first as you learn how your body reacts to nootropic compounds. Once you have determine how Piracetam works and are interested in trying a more potent nootropic, than Noopept may be a good choice.
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